Biogenic nano-system for targeted delivery of bioactive ingredients on dysbiosis biofilm involved in gingivitis and periodontitis – BioNanoGum

Project code: PN-III-P2-2.1-PED-2019-4527

Project coordinator – National Institute for Research & Development in Chemistry and Petrochemistry – ICECHIM, Bucharest

Principal Investigator: Dr. Chim. Diana CONSTANTINESCU-ARUXANDEI

Period of project implementation: 2020 – 2022

Total funding of the contract: 600.000 RON

Funding from the State Budget: 600.000 RON

Project Work plan

Year 2020: Phase 1 – Elaboration of experimental models (EMs) for objectives: (1) To optimize the production of bioactive components in one pot, from Kombucha fermented pollen and mushrooms; (2) To optimize the production of the hydrogel based on ingredients obtained from Kombucha fermented pollen and mushrooms; (3) To assay the efficacy on laboratory models of the hydrogel against dysbiosis biofilm and inflammation.

Year 2021: Phase 2 – Implementation of EMs for objectives: (1) To optimize the production of bioactive components in one pot, from Kombucha fermented pollen and mushrooms; (2) To optimize the production of the hydrogel based on ingredients obtained from Kombucha fermented pollen and mushrooms; (3) To assay the efficacy on laboratory models of the hydrogel against dysbiosis biofilm and inflammation.

Year 2022: Phase 3 – Optimization of EMs for objectives: (1) To optimize the production of bioactive components in one pot, from Kombucha fermented pollen and mushrooms; (2) To optimize the production of the hydrogel based on ingredients obtained from Kombucha fermented pollen and mushrooms; (3) To assay the efficacy on laboratory models of the hydrogel against dysbiosis biofilm and inflammation.