Through nanotechnology towards the next generation dental restorative materials
The solution developed in the research project will lead to a completion of the teeth treatment through the possibility of having antibacterial properties and slow release after the cavity is closed, with enhanced mechanical properties.
The main goal of the project is to propose a potential dental restorative material with simultaneous antibacterial properties and enhanced mechanical strength, based on substituted apatitic nanomaterials (decorated with metallic nanoparticles) and natural compounds, applicable in cement base (glass-ionomer cements).
Contracting authority: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI)
Implementation period: 09/05/2022-31/12/2024
Budget: 1.200.000 lei
Project director: Dr. Habil. Radu Claudiu Fierăscu
The scientific concept of the project is based on some specific logical steps:
S1. Synthesis of modified apatitic nanomaterials (MAN), substituted with different metals such as zinc, silver, titanium etc., and further decorated with mono or bimetallic phytosynthesized nanoparticles and metallic oxides nanoparticles (such as silver and silver oxide nanoparticles, zinc and zinc oxides nanoparticles, silver/zinc bimetallic nanoparticles, etc.), with controlled morphologies and properties;
S2. Demonstration of their enhanced properties;
S3. Enriching the MAN with natural compounds (commercially available polyphenols, such as eugenol, gallic acid, or catechin, for example) – NNC;
S4. Obtaining nanoparticle-based platforms (incorporation of apatitic materials enhanced with natural compounds in glass-ionomer cements – NGI);
S5. Demonstration of the enhanced properties of the obtained
nanoparticle-based platforms (NGI);
S6. Demonstration of their efficiency in the laboratory model (simulated conditions);
S7. Validation of the proposed solution.
The main goal of the project is to propose a potential dental restorative material with simultaneous antibacterial properties and enhanced mechanical strength, based on substituted apatitic nanomaterials (decorated with metallic nanoparticles) and natural compounds, applicable in cement base (glass-ionomer cements). The degree of novelty of the proposed project emerges from the properties of the proposed material related with potential final application: simultaneous antibacterial and enhanced mechanical strength of the developed nanomaterials-based structures, applicable in the cement base (glass-ionomer cements).
The specific objectives that will ensure the achievement of project aim are:
SO1. development of substituted apatitic materials with enhanced antimicrobial properties;
SO2. phytosynthesis of mono and bimetallic nanoparticles based on “green chemistry” approaches (with extracts obtained from autochthonous plants belonging to the Lamiaceae family – Thymus serpyllum L., 1753, Satureja hortensis L., 1753, Melissa officinalis L., Mentha spicata L., etc.) and their application for the decoration of the apatitic materials, in order to obtain modified apatitic nanomaterials (MAN) with enhanced antimicrobial properties
SO3. enrichment of the MAN with natural compounds (NNC)
SO4.incorporation of NNC in glass-ionomer cements and the demonstration of their efficiency
Development of apatitic nanostructures with potential use in improving current dental restorative materials.
Deployment period: 09/05/2022 – 31/12/2022
Optimizing the decoration of apatitic materials. Enrichment of apatitic materials modified with natural compounds – part I.
Deployment period: 01/01/2023 – 31/12/2023
Enrichment of apatitic materials modified with natural compounds – part II. Incorporation of modified apatitic materials enhanced with natural compounds in glass ionomer cements (for obtaining platforms based on nanomaterials – NGI) and study of their influence on the mechanical properties of GIC. Demonstration and validation of the improved properties of the obtained NGIs.
Deployment period: 01/01/2024 – 31/12/2024
Institutional & personal awards