Evaluation of the exploatation Potential of Porous Materials in the tREatment of Microbiota-related dISeasEs

PREMISE

PN-III-P2-2.1-PED-2019-4018 (524PED/2020)

Nowadays, especially in the case of children, the awareness about the importance of the microbiota is well known, therefore after an antibiotic treatment, the prescription of probiotics is frequently needed. In recent years, great emphasis has been placed on the development of micro and mesoporous materials (MMM) loaded with biological active agents, but few research papers discuss the impact of functionalized MMMs on microbiota.

Project goal

The scope of the current project proposal is to develop novel micro-and mesoporous materials (MMMs) using recent synthesis methods and to further functionalize these materials for developing better performances in order to be used as drug delivery systems (DDS), especially for microbiota-related diseases.

Contracting authority: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI)

Implementation period: 23/10/2020-20/10/2022

Budget: 175.000 lei

Project responsible: Dr. Habil. Irina Fierăscu

  • Partners
  • General objectives
  • Phase I
  • Phase II
  • Phase III
  • Results dissemination
Partners

Coordinator:

University POLITEHNICA of Bucharest – National Center for Micro and Nanomaterials

Project director: Assoc. prof. dr. eng. Denisa Ficai

Partner 1:

National Institute for Research & Development in Chemistry and Petrochemistry – ICECHIM,

Project responsible: Dr. Habil. Irina Fierăscu

Partner 2:

Stefan S. Nicolau Institute of Virology,

Project responsible: Dr. Coralia Bleotu


Read more

General objectives

The scope of the current project proposal is to develop novel micro-and mesoporous materials (MMMs) using recent synthesis methods and to further functionalize these materials for developing better performances in order to be used as drug delivery systems (DDS),especially for microbiota-related diseases.

In the current project 3 general objectives were taken into account, realized by means of several specific objectives, as follows:

GO1. Exploitation of research results obtained by the applicants for the establishment and development of novel, innovative drug delivery systems.

GO2. Laboratory validation of a technology which aims to obtain novel biosystems, establishing and proving the properties of the final products and facilitating the technological transfer. This objective will be accomplished by fabricating a final product consisting of a biocompatible drug delivery system and assessing the in-vitro biological interactions together with its biochemical stability and drug release kinetics, bringing the concept several steps closer to industrial application.

GO 3. Consolidation and protection of intellectual property rights regarding the materials elaborated within the boundaries of the project.

Phase I

Fabrication of micro-and mesoporous materials (MMM).

Activities carried out by the partner ICECHIM:

  • Design of porosity and size according to synthesis conditions (template agents, pH, phase diagram, etc.) to selectively load either hydrophobic or hydrophilic substances.
Phase II

Surface modification and development of drug delivery systems based on MMMs.

Activities carried out by the partner ICECHIM:

  • Loading and release of biological active agents (BAA);
  • Results dissemination.
Phase III

Development of triggering mechanisms for the drug release control.

Activities carried out by the partner ICECHIM:

  • Evaluation of the triggered MMMs.
  • Evaluation of the release profile.
  • Results dissemination.
Results dissemination

Scientific meetings:

  1. Environmentally-friendly solutions based on nano delivery systems for healthcare applications – a short review, Roxana Ioana Brazdis, Toma Fistos, Anda Maria Baroi, Irina Fierascu, Radu Claudiu Fierascu, Denisa Ficai, Anton Ficai, CONFERINȚA NAȚIONALĂ ŞTIINŢIFICĂ DE TOAMNĂ a AOSR 23 – 27 noiembrie 2020

Inventions exhibitions:

  1. EUROINVENT European Exhibition Of Creativity And Innovation Iași

ISI papers published:

  1. Fierascu, R.C.; Fierascu, I.; Chican, I.E. Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges. Coatings 2021, 11, 429. https://doi.org/10.3390/coatings11040429
  2. Fierascu, I.; Fierascu, R.C.; Ungureanu, C.; Draghiceanu, O.A.; Soare, L.C. Application of Polypodiopsida Class in Nanotechnology–Potential towards Development of More Effective Bioactive Solutions. Antioxidants 2021, 10, 748. https://doi.org/10.3390/antiox10050748
  3. Baroi, A.M.; Popitiu, M.; Fierascu, I.; Sărdărescu, I.-D.; Fierascu, R.C. Grapevine Wastes: A Rich Source of Antioxidants and Other Biologically Active Compounds. Antioxidants 2022, 11, 393. https://doi.org/10.3390/antiox11020393
  4. Petrisor, G.; Ficai, D.; Motelica, L.; Trusca, R.D.; Bîrcă, A.C.; Vasile, B.S.; Voicu, G.; Oprea, O.C.; Semenescu, A.; Ficai, A.; Popitiu, M.I.; Fierascu, I.; Fierascu, R.C.; Radu, E.L.; Matei, L.; Dragu, L.D.; Pitica, I.M.; Economescu, M.; Bleotu, C. Mesoporous Silica Materials Loaded with Gallic Acid with Antimicrobial Potential. Nanomaterials 2022, 12, 1648.