Transdisciplinary approach for development of technological solutions for target compounds recovery from agro side-streams
E! 13365 – TARDIS
PN-III-P3-3.5-EUK-2019-0226 (220/2020)
Biowaste valorisation is an attractive approach in the framework of the EU Waste Management policies and the development of a circular economy. Wastes from biostreams and different bio-based sources are being under-utilized as potential resource of valuable compounds.
Project goal
The general objective of the project is to underline, optimize and apply an integrate technology of sustainable and enhanced production of natural extracts with high content of biological active compounds from side streams of agricultural industries applicable for obtaining smart formulations for disorders of the 21st century, for which continuous research is carried out.
International initiative – EUREKA
Project type: EUREKA Traditional (Network)
Contracting authority at national level: Executive Unit for Financing Higher Education, Research, Development and Innovation (UEFISCDI)
Implementation period: 28/12/2020-25/12/2026
Budget: 493.200 lei
Project responsible: Dr. Habil. Radu Claudiu Fierăscu
International consortium coordinator:
PharmacoIdea Ltd., Szeged, Hungary
International project director: Tamas Letoha, MD, PhD
National consortium coordinator:
National project director: Dr. Eng. Daniela Ionescu
Partner 1:
National Institute for Research & Development in Chemistry and Petrochemistry – ICECHIM,
Project responsible: Dr. Habil. Radu Claudiu Fierăscu
Partner 2:
University of Agronomic Sciences and Veterinary Medicine of Bucharest
Project responsible: Assoc. prof. Dr. Alina Orțan
The general objective of the project is to underline, optimize and apply an integrate technology of sustainable and enhanced production of natural extracts with high content of biological active compounds from side streams of agricultural industries applicable for obtaining smart formulations for disorders of the 21st century, for which continuous research is carried out.
The main idea of the project is to process plants by-products rich in nutritional and bioactive compounds into formulations to be used in pharma industry with the following benefits: the use of obtained extracts and target compounds for the prevention / treatment of age-related neurodegenerative disorders such as Alzheimer’s disease; minimizing the amount of plant waste by recovering the target compounds from the by-products; increasing the potential of the pharmaceutical and food market by designing new functional ingredients; increasing the quality of life.
Complex study of screening plant waste with potential for use after basic processing. Optimization of an innovative technology for obtaining high-yield polyphenolic compounds from vegetable waste (Part I).
Deployment period: 28/12/2020 – 31/12/2021
Activities carried out by the partner ICECHIM:
- Phytochemical screening of available raw materials from plant waste;
- Development of quantitative methods for the analysis of compounds from plant waste (evaluation of target compound concentrations by screening samples using modern analytical techniques);
- Identification of extraction methods to ensure the necessary concentrations in the extracts obtained;
- Dissemination activities.
Optimization of an innovative technology for obtaining high-yield target compounds from vegetable waste as well as natural extracts (Part II).
Deployment period: 01/01/2022 – 31/12/2022
Activities carried out by the partner ICECHIM:
- Finalization of advanced solutions for obtaining extracts from vegetable waste;
- Characterization of compounds before / after separation and purification;
- Dissemination activities.
Demonstration of the possibility of applying the technology of obtaining phenolic compounds on an industrial scale.
SWOT analysis of value-added products from pilot batches.
Development of technical documentation for the proposed technologies and products.
Deployment period: 01/01/2023 – 26/12/2023
Activities carried out by the partner ICECHIM:
- Physico-chemical characterization of pilot batch to demonstrate the functionality of the proposed technologies;
- Contributions to the elaboration of the documentation related to the pilot batch;
- Contributions to the elaboration of the patent application;
- Dissemination and communication.
The implementation of the activities of joint Project will provide innovative solutions, helping to prevent health issues, changing the nutrition habits and providing new food products with enriched functionality and biological value.
Estimated results:
1. a prototype of therapeutic powders provided in order to be used by the Hungarian SME;
2. several therapeutic products, made from these powders with impact on health;
3. the Project results will be made public and it will constitute a premise for new ideas, projects and support for reason to deal the public health problems;
4. open new trade routes between Hungary and Romania.
ISI papers
- Fierascu R.C.; Fierascu I.; Chican I.E. Natural Ingredients in Functional Coatings—Recent Advances and Future Challenges. Coatings 2021, 11, 429. https://doi.org10.3390/coatings/11040429
- Fierascu, I.C.; Fierascu, I.; Baroi, A.M.; Ungureanu, C.; Ortan, A.; Avramescu, S.M.; Somoghi, R.; Fierascu, R.C.; Dinu-Parvu, C.E. Phytosynthesis of Biological Active Silver Nanoparticles Using Echinacea purpurea L. Extracts. Materials 2022, 15, 7327. https://doi.org/10.3390/ma15207327
- Baroi, A.M.; Popitiu, M.; Fierascu, I.; Sărdărescu, I.-D.; Fierascu, R.C. Grapevine Wastes: A Rich Source of Antioxidants and Other Biologically Active Compounds. Antioxidants 2022, 11, 393. https://doi.org/10.3390/antiox11020393
- Fierascu, I.C.; Fierascu, I.; Baroi, A.M.; Ungureanu, C.; Spinu, S.; Avramescu, S.M.; Somoghi, R.; Fierascu, R.C.; Dinu-Parvu, C.E. Phytosynthesis of Silver Nanoparticles Using Leonurus cardiaca L. Extracts. Materials 2023, 16, 3472. https://doi.org/10.3390/ma16093472
- Marchidan, I.G.; Ortan, A.; Marcu Spinu, S.; Avramescu, S.M.; Avram, I.; Fierascu, R.C.; Babeanu, N. Chemical Composition and Biological Properties of New Romanian Lavandula Species. Antioxidants 2023, 12, 2127. https://doi.org/10.3390/antiox12122127
Participation to scientific meetings
Anda Maria Baroi, Radu Claudiu Fierascu, Toma Fistos, Roxana Ioana Brazdis, Raluca Somoghi, Lia-Mara Ditu, Irina Fierascu, Green synthesis of bimetallic nanostructures using vine shoots extracts – characterization and antimicrobial effects, “PRIORITIES OF CHEMISTRY FOR A SUSTAINABLE DEVELOPMENT – PRIOCHEM” 27-29 October 2021
Anda Maria Baroi, Radu Claudiu Fierascu, Roxana Ioana Brazdis, Toma Fistos, Irina Fierascu, General applications of nanomaterials delivery systems based on bioactive compound related to human health, International Congress of „Apollonia” University from Iași, Edition XXXI, 1-3 March, 2021, Iași, Romania
Anda Maria Baroi, Radu Claudiu Fierascu, Roxana Ioana Brazdis, Toma Fistos, Lia-Mara Ditu, Raluca Somoghi, Irina Fierascu, Viticultural waste management for obtaining nanostructures with medical applications, International Scientific Conference, Applications of Chemistry in Nanosciences and Biomaterials Engineering – NanoBioMat 25-26 June 2021 – Best Poster Award
NeXT-Chem: Innovative cross-sectoral technologies, IVth Edition, INCDCP-ICECHIM, Bucharest – ROMANIA May 19-20, 2022, Phytosynthesis of mono and bimetallic nanostructures using vine shoots extracts -characterization and amtimicrobial effect – Anda Maria BAROI, Radu Claudiu FIERĂSCU, Toma FISTOȘ, Roxana Ioana BRAZDIȘ, Lia-Mara DITU, Raluca ȘOMOGHI, Irina FIERASCU
The International Symposium “PRIORITIES OF CHEMISTRY FOR A SUSTAINABLE DEVELOPMENT”PRIOCHEM – XVIII-th Edition. October 26-28, 2022, DEVELOPMENT OF PHYTOSYNTHESIZED NANOPARTICLES WITH ENHANCED BIOLOGICAL PROPERTIES, Ioana Cătălina FIERĂSCU, Irina FIERĂSCU, Anda Maria BAROI, Camelia UNGUREANU, Alina ORȚAN, Simona SPINU, Sorin Marius AVRAMESCU, Raluca ȘOMOGHI, Radu Claudiu FIERĂSCU, Valetina ANUTA, Cristina Elena DINU-PÂRVU
Virtual International Scientific Conference on “Applications of Chemistry in Nanosciences and Biomaterials Engineering” NanoBioMat 2023 – Summer Edition, 28-30 June 2023, Development of Natural Extracts by Valorizing Agrotechnical Waste from Vineyards. Daniela-I. Sărdărescu, Radu C. Fierăscu, Diana E. Vizitiu, Anda M. Baroi, Alin Din, Irina Fierăscu, Cătălina I. Guță, Elena C. Buciumeanu
Capitalization of vegetal wastes for industrial application: a method for reducing the associated pollution and for increasing the quality of life, Radu Claudiu Fierascu, Anda Maria Baroi, Roxana Ioana Matei (Brazdis), Toma Fistos, Irina Fierascu, Alina Ortan, Simona Spinu, Daniela Ionescu, “Priorities of Chemistry for a Sustainable Development” PRIOCHEM XIXth Edition, 11-13 Octombrei 2023, Bucuresti
Participation at Inventions and Innovations Exhibits
Radu Claudiu Fierascu, Irina Fierascu, Alina Ortan, Daniela Ionescu, Transdisciplinary approach for development of technological solutions for target compounds recovery from agro side-streams – E!13365/ TARDIS, EUROINVENT – European Exhibition of Creativity and Innovation. 13th edition of EUROINVENT, 20-22 May 2021. Gold Medal
Radu Claudiu Fierascu, Irina Fierascu, Alina Ortan, Daniela Ionescu, Transdisciplinary approach for development of technological solutions for target compounds recovery from agro side-streams – E!13365/ TARDIS, The International Exhibition of Research, Innovations and Inventions PRO INVENT, 20-22 October 2021. Excellence Diploma
Radu Claudiu Fierascu, Irina Fierascu, Alina Ortan, Daniela Ionescu, Transdisciplinary approach for development of technological solutions for target compounds recovery from agro side-streams – E!13365/ TARDIS, The International Exhibition of Inventions and Innovations “TRAIAN VUIA – 2021”, 12-14 October 2021. Gold Medal
Radu Claudiu Fierascu, Irina Fierascu, Alina Ortan, Daniela Ionescu, Transdisciplinary approach for development of technological solutions for target compounds recovery from agro side-streams – E!13365/ TARDIS, Kaohsiung nternational Invention & Design EXPOTaiwan – 2-4 December 2021. Gold Medal
Ecological extracts from burdock waste obtaining process and potential therapeutic use – Alina Ortan, Simona Spinu, Radu Fierascu, Anda Baroi, Irina Fierascu, Toma Fistos, EUROINVENT European Exhibition Of Creativity And Innovation Iași, 2022
IDEA (IDEA, Novelty, Invention and craft) International Exhibition, Abony, Hungary, Ecological extracts from burdock waste obtaining process and potential therapeutic use – Alina Ortan, Simona Spinu, Radu Fierascu, Anda Baroi, Irina Fierascu, Toma Fistos
International Invention Innovation Competition in Canada – ICAN, Ecological extracts from burdock waste obtaining process and potential therapeutic use – Alina Ortan, Simona Spinu, Radu Fierascu, Anda Baroi, Irina Fierascu, Toma Fistos
International Exhibition of Inventions – INVENTICA Iași, Ecological extracts from burdock waste obtaining process and potential therapeutic use – Alina Ortan, Simona Spinu, Radu Fierascu, Anda Baroi, Irina Fierascu, Toma Fistos
PRO INVENT 2022 The 20th edition of the International Exhibition of Research, Innovations and Inventions, Ecological extracts from burdock waste obtaining process and potential therapeutic use – Alina Ortan, Simona Spinu, Radu Fierascu, Anda Baroi, Irina Fierascu, Toma Fistos
