National Institute for Research & Development in Chemistry and Petrochemistry

ICECHIM

G6: Biotechnology & bioanalysis

About us


The 6th Research Group carries out research activities in the field of Biotechnology & Bioanalysis, the research directions being: 1. Biotechnologies for environmental protection and remediation  Biodegradation of waste and pollutants  Biotechnologies to remedy contamination 2. Agri-food and industrial biotechnologies for obtaining biologically active products  Microbial technologies for obtaining substances with antimicrobial properties  Pharmaceutical biotechnologies  Biotechnologies for obtaining products with uses in the light chemical and food industry (new sources of enzymes) 3. Bioanalysis methods for quality control of products and biotechnological processes in the field of health, environment and agri-food  Advanced methods and techniques of analysis, control and quality assurance of biotechnological substances and products  Development of sensors, biosensors and immunosensors for the detection of toxic compounds, pollutants and metabolites in the environment and agri-food products. Within the 6th reasearch group, there is a Collection of Microorganisms that contains fungi, yeasts and bacteria, which allows and supports the biotechnological approach of our research activities. Microorganisms have the ability to adapt to a variety of environmental conditions, their versatility making them useful for various biotechnological applications, such as removing pollutants from the environment, bioremediation or transformation into harmless compounds such as carbon dioxide and water. Enriching the collection of microorganisms by isolating them from various sources and maintaining them are of permanent concerns of microbiologists. The 6th research group is a multidisciplinary team, consisting in 2 chemists, 2 biochemists, 2 biologists, 1 engineer and 1 technician (3 CSI, 2 CSII, 2 CSIII; 6 doctors in science). The specialists our group actively participate in:  Evaluation of scientific research projects carried out at national (UEFISCDI) and European level (INTAS experts)  Review activity as references of specialized magazines from Romania and abroad – Roum. Biotechnol. Letters, Biosensors & Bioelectronics (Elsevier), Food Biotechnology, Sensors, Toxins, Biomachine, Biosensors, Bioelectrochemistry, Biomedical and Environmental Science, etc.  Supporting the activity of the Romanian Society of Bioengineering and Biotechnology (SRBB) (www.srbb.ro), an organization affiliated since 1993 to the European Biotechnology Federation  Didactic activities carried out in higher education institutions (University of Bucharest, Polytechnic University of Bucharest, etc.). Through Capacity project 49/CP/I/2007, the laboratories of the Biotechnology & Bioanalysis team were arranged according to GLP norms as follows:  Microbiology Laboratory (respecting the Rules of Good Laboratory Practice-RBPL regarding the flow of personnel, materials and samples)  Laboratory for (BIO) Sensors and optical methods of bioanalysis  Laboratory for Separation Methods

Team


Senior Scientist 1st degree, General Manager of INCDCP-ICECHIM

Dr. biochem.

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Senior Scientist 1st degree, Leader of Biotechnology & Bioanalysis Research Group

Dr. Chem.

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Senior Scientist 2nd degree, Deputy leader of Biotechnology & Bioanalysis Research Group

Dr. Chem.

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Senior Scientist 1st degree

Dr. Sc. HDR

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Senior Scientist 2nd degree

Engineer

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Senior Scientist 3rd degree

Dr. Biology

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Senior Scientist 3rd degree

Dr. Biology

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Extension: 170

Technician

Techn.

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Research equipment


International projects


National projects


Results


  • Publications
  • Books
  • Conferences
  • Patents
  • Other
Publications

Marinela Bostan, Mirela Mihaila, Georgiana Gabriela Petrica-Matei, Nicoleta Radu, Razvan Hainarosie, Cristian Dragos Stefanescu, Viviana Roman and Carmen Cristina Diaconu

Resveratrol Modulation of Apoptosis and Cell Cycle Response to Cisplatin in Head and Neck Cancer Cell Lines

Int. J. Mol. Sci. 2021, 22, 6322

doi.org/ 10.3390/ijms22126322

Melania-Liliana Arsene, Iuliana Raut, Mariana Calin, Maria-Luiza Jecu, Mihaela Doni and Ana-Maria Gurban

Versatility of Reverse Micelles: From Biomimetic Models to Nano (Bio)Sensor Design

Processes 2021, 9, 345

doi.org/10.3390/pr9020345

Iuliana Raut, Mariana Calin, Zina Vuluga, Florin Oancea, Jenica Paceagiu, Nicoleta Radu, Mihaela Doni , Elvira Alexandrescu, Violeta Purcar, Ana-Maria Gurban, Ionela Petre and Luiza Jecu 1,*

Fungal Based Biopolymer Composites for Construction Materials

Materials 2021, 14, 2906

doi.org/ 10.3390/ma14112906

Iuliana Raut, Mariana Calin, Luiza Capra, Ana-Maria Gurban , Mihaela Doni, Nicoleta Radu and Luiza Jecu

Cladosporium sp. Isolate as Fungal Plant Growth Promoting Agent

Agronomy 2021, 11, 392

doi.org/10.3390/agronomy11020392

Bostan M., Petrică-Matei G. G., Radu N., Hainarosie R., Stefanescu C. D., Diaconu C. C., Roman V.

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

Nutrients, Vol 12, 2596, August 2020, doi:10.3390/nu12092596

doi:10.3390/nu12092596

Books

Calin M; Raut I.; Gurban A.-M.; Doni M.; Radu N.; Jecu L.

Archaeometrical study of selected objectives from Golesti Museum of Viticulture and Pomiculture

Chapter5: Microbial contamination of wooden cultural heritage artifacts of selected objectives from Golesti Museum

ISBN978-619-91466-1-3

Radu N.; Babeanu N.; Cornea P.; Calin M.; Jecu L.; Gurban A.M; Doni, M;

Archaeometrical study of selected objectives from Golesti Museum of Viticulture and Pomiculture

Chapter 4:Paintings characteristics from inside of wooden church achieved in the period 1750-1850

ISBN 978-619-91466-1-3

M Calin, I Raut, ML Arsene, M Doni, AM Gurban, L Jecu

Practical exemples regarding the valorization of cultural heritage through archaeometry studies using nuclear techniques and other scientific methods

Chapter 4. Isolation and identification of microorganisms involved in the biodeterioration of cultural heritage artifacts

ISBN: 978-973-0-27114-0

I Raut, M Calin, ML Arsene, M Doni, AM Gurban, L Jecu

Valorization of cultural heritage through archaeometry studies using nuclear techniques and other scientific methods. General considerations and short literature survey

Chapter 5. Microbial deterioration of textile and wood artifacts

ISBN: 978-973-0-27114-0

F. Oancea, I. Raut, T.E .Sesan, M. Doni, M. Popescu, V. Zamfiropol-Cristea, L. Jecu

Trichoderma spp. – applications in agriculture and horticulture

Chapter 8 – Formulation of the Multifunctional Trichoderma Strains

ISBN 978-606-16-0900-0

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Conferences

Marilena Gabriela Zaharie, Mihai Caramihai, Montserrat Adroguer, Paqui Blánquez, Tom Kuppens and Nicoleta Radu

Virtual Reality and Mixed Reality Education: A Solution for Today’s Education in a Circular Bioeconomy

16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 28–30 October 2020.

Mariana Călin, Iuliana Răut, Ana-Maria Gurban, Mihaela Doni, Nicoleta Radu, Gelu Vasilescu and Luiza Jecu

Assessment of Biological Contamination from Wooden Artifacts of Golesti Museum

16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 28–30 October 2020

Iuliana RĂUT, Mariana CĂLIN, Ana-Maria GURBAN, Luiza CAPRĂ, Mihaela DONI, Nicoleta RADU, Gelu VASILESCU and Luiza JECU

A Biotechnological Process for Valorizing Poultry Feathers through Keratinolytic Cladosporium Isolates

16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 28–30 October 2020.

Naomi Tritean, Mariana Călin, Iuliana Răut, Ana-Maria Gălan, Alexandru Vlaicu, Diana Constantinescu-Aruxandei and Florin Oancea

Extraction of Proteins from Microalgae Using Lytic Enzymes Produced by Trichoderma Strains

16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 28–30 October 2020.

Nicoleta Radu, Narcisa Babeanu, Petruta Cornea, Mariana Calin , Luiza Jecu, Iuliana Raut, Ana Maria Gurban and Mihaela Doni

Painting Degradation from Inside Wooden Churches Achieved in the Period 1750–1850

16th International Symposium “Priorities of Chemistry for a Sustainable Development” PRIOCHEM, Bucharest, Romania, 28–30 October 2020.

Patents

Oancea Florin, Velea Sanda, Popescu Mariana, Răut Iuliana

Process for conditioning biostimulating microorganisms for plants, in the form of an effervescent tablet

131927/30.08.2019

F Oancea, I Raut, TE Sesan, M Doni, M Popescu, L Jecu

Procedure for selecting consortia of microorganisms for the treatment of plant material

131224B1/2019

F Oancea, I. Raut, Abraham Beata, Szabolcs Lanyi Stefan, M Doni, L Jecu

High yield process for the selection of consortia of microorganisms with action to stimulate cultivated plants

131225

Oancea F, Sesan T E, M Doni, Raut I, Vlăsceanu G A, Negru G. L Jecu

Silicium-based biostimulating composition for foliar application

3/2/30.01.2019

F Oancea, I Raut, TE Sesan, M Doni, M Popescu, L Jecu

Procedure for selecting consortia of microorganisms that release and solubilize biosilicium from plant material

131828B1/2019

Other

R.M. Ion; N. Ion; L. Iancu; N. Radu

Silver Medal awarded to Patent request to EUROINVENT, 11th Edition, European Exhibition of Creativity and Innovation, May 18, 2019, Iasi, Romania.

R.M. Ion, N. Ion, L.Iancu, N. Radu

Gold Medal awarded to Patent request 17th edition of PROINVENT, March 20-22, 2019, Cluj Napoca, Romania